Waiting
Elaborazione accesso...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Neuroscience / Optic Nerve Transection: A Model of Adult Neuron…
JoVE Journal
Neuroscience

È necessario avere un abbonamento a JoVE per visualizzare questo Contenuto. Accedi o inizia la tua prova gratuita.

JoVE Journal Neuroscience
Optic Nerve Transection
 
Click here for the English version

Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System

Article DOI: 10.3791/2241-v • 12:06 min • May 12th, 2011
May 12th, 2011 •
*1, *1, 1
1Department of Surgery, University of Toronto
* These authors contributed equally

Capitoli

Riepilogo
Automatic Translation

Please note that all translations are automatically generated.

Click here for the English version.

Optic Nerve transection is a widely used model of adult CNS injury. Ninety percent of retinal ganglion cells (RGCs) whose axons are completely transected (axotomy) die within 14 days after axotomy. This model is easily amenable to experimental manipulations and highly reproducible.

Tags

Optic Nerve Transection Adult Neuron Apoptosis Central Nervous System Retinal Ganglion Cells Optic Nerve Axotomized Apoptotic Neuronal Cell Death CNS Model Vitreous Chamber Drug Delivery Intraocular Injections Short Interfering RNAs (siRNAs) Plasmids Viral Vectors Superior Colliculus Apoptotic Mechanisms Neuronal Population Cell Survival Quantification Fluorescent Tracer
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter