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JoVE Journal Neuroscience
Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS
 
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Methods for Experimental Manipulations after Optic Nerve Transection in the Mammalian CNS

Article DOI: 10.3791/2261-v • 11:03 min • May 12th, 2011
May 12th, 2011 •
*1, *1, 1
1Department of Surgery, University of Toronto
* These authors contributed equally

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Optic Nerve transection is a widely used model of adult CNS injury. This model is ideal for performing a number of experimental manipulations that target the retina globally or directly target the injured neuronal population of retinal ganglion cells.

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Optic Nerve Transection Experimental Manipulations Mammalian CNS Retinal Ganglion Cells Optic Nerve Axotomized Apoptotic Neuronal Cell Death Vitreous Chamber Drug Delivery Intraocular Injections Viral Vectors Plasmids SiRNAs Adeno-Associated Virus (AAV) Vectors RGCs Targeting Superior Colliculus Apoptotic Mechanisms
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