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Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice
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JoVE Journal Medicina
Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice

Pressure Controlled Ventilation to Induce Acute Lung Injury in Mice

DOI:
10.3791/2525-v

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07:55 min

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May 05, 2011

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, ,
1Department of Anesthesiology,University of Colorado

Capitoli

  • 00:05Titolo
  • 01:10Surgical Preparation
  • 02:53Ventilator-induced Lung Injury
  • 04:52Sample Collection
  • 07:17Measurement of Lung Injury
  • 07:36Conclusion

Summary

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A murine model for ventilator induced lung injury is an important tool to study an acute lung injury in vivo. Here, we report an easy applicable in situ model for acute lung injury using high-pressure mechanical ventilation to induce acute failure of the lung.

Tags

Pressure Controlled VentilationAcute Lung InjuryALIMiceMurine ModelsMechanical VentilationGenetic TargetsPharmacological TargetsPulmonary EdemaPulmonary Gas ExchangeVentilator-induced Lung InjuryC57BL/6 MiceTracheotomyInspiratory Peak PressureOutcome ParametersWet-to-dry RatioBronchoalveolar Fluid Albumin ContentMyeloperoxidase ContentPulmonary InflammationTreatment GroupsGenotypesGene-targeted Deletion

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