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Silicon Microchips for Manipulating Cell-cell Interaction
 

Silicon Microchips for Manipulating Cell-cell Interaction

Article DOI: 10.3791/268-v • 23:21 min • August 30th, 2007
August 30th, 2007 •
1, 1
1Laboratory for Multiscale Regenerative Technologies, MIT - Massachusetts Institute of Technology

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This article describes an experimental approach for dynamic regulation of cell-cell interactions between adherent cells on a micrometer scale. Manipulation of intercellular communication between hepatocytes and stromal cell is demonstrated. The developed platform enables investigation of cell-cell interactions in a variety of biological processes, including development and pathogenesis.

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Silicon Microchips Cell-cell Interaction Cellular Microenvironment Mammalian Tissues Malignant Transformation Neighboring Stroma Conventional Techniques Spatial And Dynamic Elements Micromechanical Reconfigurable Culture (RC) Micromachined Silicon Substrate Mechanical Repositioning Intercellular Communication Co-cultures Of Hepatocytes And Non-parenchymal Cells Soluble Signaling RC System Handling Device Parts Actuating Between Gap And Contact Configurations Preparing Substrates For Culture Multi-step Cell Seeding Process Confluent Cell Monolayers Live Microscopy Experimental Configurations
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