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Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract
 

Characterization of Molecular Mechanisms of In vivo UVR Induced Cataract

Article DOI: 10.3791/4016-v • 13:56 min • November 28th, 2012
November 28th, 2012 •
1,2, 2, 2
1St. Erik's Eye Hospital, Karolinska Institutet, 2Gullstrand lab, Section for Ophthalmology, Department of Neuroscience, Uppsala University

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Cataract is the leading cause of blindness in the world. Solar ultraviolet radiation (UVR) is the main risk factor for cataract development. An animal model of far UVR-B induced cataract was developed. In this article we describe methods for investigation of cataract formation: exposure to UVR, quantitative RT-PCR and immunohistochemistry.

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Cataract Blindness World Health Organization Clouding Of The Lens Multi-factorial Disease Diabetes Smoking Ultraviolet Radiation (UVR) Alcohol Ionizing Radiation Steroids Hypertension Animal Model Surgery Prevention Strategies Apoptosis Lens Pharmaceuticals RT-PCR Immunohistochemistry
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