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A Novel Surgical Approach for Intratracheal Administration of Bioactive Agents in a Fetal Mouse Model
 

A Novel Surgical Approach for Intratracheal Administration of Bioactive Agents in a Fetal Mouse Model

Article DOI: 10.3791/4219-v • 10:12 min • October 31st, 2012
October 31st, 2012 •
*1, *2, 2, 1, 3, 2, 2, 4, 5, 1, 2
1Molecular Virology and Gene Therapy, KU Leuven, 2Department of Woman and Child, KU Leuven, 3Neurobiology and Gene Therapy, KU Leuven, 4Division of Nuclear Medicine, KU Leuven, 5Biomedical NMR Unit/ MoSAIC, KU Leuven
* These authors contributed equally

Capitoli

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Automatic Translation

We developed a novel surgical approach for intratracheal administration of bioactive agents into the mouse fetus. The delivery route is more efficient in targeting the fetal mouse lungs than the commonly used intra-amniotic injection. This procedure has to date not been described in a mouse model.

Tags

Surgical Approach Intratracheal Administration Bioactive Agents Fetal Mouse Model Prenatal Pulmonary Delivery Therapeutic Strategies Genetic Diseases Acquired Diseases Congenital Abnormalities Inherited Abnormalities Long-term Gene Expression Short-term Gene Expression Pharmacological Intervention Neonatal Respiratory Distress Syndrome Hyperoxic Injuries Cystic Fibrosis (CF) Surfactant Deficiencies α1-antitrypsin Deficiency Prenatal Gene Therapy Early Therapeutic Intervention Fetal Organs Cell Proliferation Rate Gene Transfer Stem Cell Transfer
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