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Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion
 

Utilizing a Cranial Window to Visualize the Middle Cerebral Artery During Endothelin-1 Induced Middle Cerebral Artery Occlusion

Article DOI: 10.3791/50015-v • 07:44 min • February 22nd, 2013
February 22nd, 2013 •
1, 2, 3, 2, 1
1Department of Physiology and Functional Genomics, University of Florida, 2Department of Neurosurgery, McKnight Brain Institute, University of Florida, 3Department of Anatomical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

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This article describes a method for visualizing rat cerebral arteries through a cranial window using temporal craniectomy in order to view proximal portions of the middle cerebral artery (Figure 1). This versatile method can be combined with various techniques of drug delivery to measure cerebral artery reactivity in vivo.

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Keywords: Cranial Window Middle Cerebral Artery Endothelin-1 Ischemic Stroke Visualization Cortical Surface Dura Craniectomy Rat Cerebrum MCA Occlusion
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