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A Modified Heterotopic Swine Hind Limb Transplant Model for Translational Vascularized Composite Allotransplantation (VCA) Research
 

A Modified Heterotopic Swine Hind Limb Transplant Model for Translational Vascularized Composite Allotransplantation (VCA) Research

Article DOI: 10.3791/50475-v • 09:09 min • October 14th, 2013
October 14th, 2013 •
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1Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine

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Vascularized Composite Allotransplantations (VCA) have become a clinical reality. However, broad clinical application of VCA is limited by chronic multi-drug immunosuppression. The authors present a reliable and reproducible large animal model to translate novel immunomodulatory strategies that can minimize or potentially eliminate the need of immunosuppression in VCA.

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Keywords: Modified Heterotopic Swine Hind Limb Transplant Vascularized Composite Allotransplantation (VCA) Translational Research Immunomodulation Immunosuppression Large Animal Model Osteomyocutaneous Flap Femoral Vascular Pedicle Vascularized Bone Marrow Transplant Immune Monitoring
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