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Bioengineering

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JoVE Journal Bioengineering
Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles
 

Programming Stem Cells for Therapeutic Angiogenesis Using Biodegradable Polymeric Nanoparticles

Article DOI: 10.3791/50736-v • 09:01 min • September 27th, 2013
September 27th, 2013 •
*1, *1,2, 1,2
1Department of Orthopaedic Surgery, Stanford University, 2Department of Bioengineering, Stanford University
* These authors contributed equally

Capitoli

Riepilogo
Automatic Translation

We describe the method of programming stem cells to overexpress therapeutic factors for angiogenesis using biodegradable polymeric nanoparticles. Processes described include polymer synthesis, transfecting adipose-derived stem cells in vitro, and validating the efficacy of programmed stem cells to promote angiogenesis in a murine hindlimb ischemia model.

Tags

Stem Cells Angiogenesis Therapeutic Angiogenesis Biodegradable Polymeric Nanoparticles Vascular Growth Ischemic Diseases Gene Therapy Adipose-derived Stem Cells VEGF Hindlimb Ischemia Model
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