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Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
 

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Article DOI: 10.3791/50960-v • 08:09 min • January 7th, 2014
January 7th, 2014 •
1, 1, 2, 1
1Center for Health Sciences, SRI International, 2Department of Chemistry and Biochemistry, University of California-Santa Cruz

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Lipoxygenase (LOX) isozymes can generate products that may increase or decrease neuroinflammation and neurodegeneration. A gene-environment interaction study could identify LOX isozyme-specific effects. Using the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of nigrostriatal damage in two LOX isozyme-deficient transgenic lines allows for comparison of the contribution of LOX isozymes on dopaminergic integrity and inflammation.

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Keywords: Gene-environment Interaction Lipoxygenase Parkinson's Disease MPTP Neurodegenerative Disorders Nigrostriatal Degeneration Dopamine Tyrosine Hydroxylase Inflammation GFAP Iba-1
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