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Neuroscience

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JoVE Journal Neuroscience
Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress
 

Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress

Article DOI: 10.3791/51209-v • 09:51 min • May 7th, 2014
May 7th, 2014 •
1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4
1Laboratoire de Radiopathologie, CEA DSV iRCM SCSR, 2INSERM, U967, 3Université Paris Diderot, Sorbonne Paris Cité, 4Université Paris Sud, UMR 967

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Administration of two analogs of thymidine, EdU and BrdU, in pregnant mice allows the analysis of cell cycle progression in neural and progenitor cells in the embryonic mouse brain. This method is useful to determine the effects of genotoxic stress, including ionizing radiation, during brain development.

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Keywords: Neural Stem Cells Neural Progenitor Cells Cell Cycle Genotoxic Stress Ionizing Radiation EdU BrdU DNA Damage Response Cell Cycle Checkpoint Dorsal Telencephalon
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