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Neuroscience

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JoVE Journal Neuroscience
Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress
 

Assessing Cell Cycle Progression of Neural Stem and Progenitor Cells in the Mouse Developing Brain after Genotoxic Stress

Article DOI: 10.3791/51209-v • 09:51 min • May 7th, 2014
May 7th, 2014 •
1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4, 1,2,3,4
1Laboratoire de Radiopathologie, CEA DSV iRCM SCSR, 2INSERM, U967, 3Université Paris Diderot, Sorbonne Paris Cité, 4Université Paris Sud, UMR 967

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Administration of two analogs of thymidine, EdU and BrdU, in pregnant mice allows the analysis of cell cycle progression in neural and progenitor cells in the embryonic mouse brain. This method is useful to determine the effects of genotoxic stress, including ionizing radiation, during brain development.

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Cell Cycle Progression Neural Stem Cells Progenitor Cells Mouse Developing Brain Genotoxic Stress Cerebral Cortex Embryonic Brain DNA Damage Response EdU Injection BrdU Injection Thymidine Analogues S Phase Ventricular Margin Dorsal Telencephalon Dual Labeling Technique
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