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Bioengineering

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JoVE Journal Bioengineering
Cell-based Therapy for Heart Failure in Rat
 

Cell-based Therapy for Heart Failure in Rat: Double Thoracotomy for Myocardial Infarction and Epicardial Implantation of Cells and Biomatrix

Article DOI: 10.3791/51390-v • 09:11 min • September 22nd, 2014
September 22nd, 2014 •
1, 1, 1, 1, 1
1Cardiology, Department of Medicine, University of Fribourg

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Implantation of a biograft to treat myocardial infarction induced by LAD ligation in a rodent model has conventionally required two open-heart surgeries. In order to reduce mortality and provide optimal conditions for fixation of solid and gelatinous biomatrices associated with cells, minimally invasive procedures have been developed.

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Cell-based Therapy Heart Failure Rat Thoracotomy Myocardial Infarction Epicardial Implantation Cells Biomatrix Biomaterials Myocardial Cell Delivery Rodent Model Left Anterior Descending Artery (LAD) Ligation Sternotomy Post-surgery Recovery Minimally Invasive Surgical Procedures Biografts Solid Matrix Gel Matrix Heart Function Echocardiography Scar Formation Post-operative Mortality
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