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Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound
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JoVE Journal Medicina
Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

DOI:
10.3791/52200-v

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10:08 min

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December 02, 2014

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, , , , , , , ,
1Department of Biomedical Engineering,Johns Hopkins University, 2Department of Anesthesiology and Critical Care Medicine,Johns Hopkins University, 3Department of Medicine (Cardiology),Johns Hopkins University, 4The Australian School of Advanced Medicine,Macquarie University

Capitoli

  • 00:05Titolo
  • 01:15Preparation
  • 02:25Catheter Insertion
  • 03:38Blood Pressure Catheter Insertion
  • 06:06Measuring Aortic Diameter
  • 08:55Results: Aortic Stiffness In Vivo
  • 09:44Conclusion

Summary

Traduzione automatica

Traduzione automatica

We describe a technique for measuring aortic stiffness from its pressure-diameter relationship in vivo in mice. Aortic diameter is recorded by ultrasound and aortic pressure is measured invasively with a solid-state pressure catheter. Blood pressure is changed incrementally and the resulting diameter is measured.

Tags

Aortic StiffnessIn VivoMiceUltrasoundPressure-diameter RelationshipArterial ComplianceCardiovascular DiseaseAgingVasoactive DrugsPhenylephrineSodium NitroprussideAortic DiameterAortic Blood Pressure

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