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Oxygen-Glucose Deprivation and Reoxygenation as an In Vitro Ischemia-Reperfusion Injury Model for Studying Blood-Brain Barrier Dysfunction
 

Oxygen-Glucose Deprivation and Reoxygenation as an In Vitro Ischemia-Reperfusion Injury Model for Studying Blood-Brain Barrier Dysfunction

Article DOI: 10.3791/52699-v • 08:56 min • May 7th, 2015
May 7th, 2015 •
1,2, 2, 1,2, 1,2
1Department of Surgery, Texas A&M University Health Science Center College of Medicine, 2Department of Surgery, Baylor Scott & White Health

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Ischemia-Reperfusion (IR) injury is associated with a high rate of morbidity and mortality. The goal of the in vitro model of oxygen-glucose deprivation and reoxygenation (OGD-R) described here is to assess the effects of ischemia reperfusion injury on a variety of cells, particularly in blood-brain barrier (BBB) endothelial cells.

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Oxygen-glucose Deprivation Reoxygenation In Vitro Ischemia-reperfusion Injury Model Blood-brain Barrier Dysfunction Ischemic Strokes IR Injury Free Radicals Vasogenic Brain Edema Tight Junctions Endothelial Cells BBB Permeability Oxidative Stress Metabolic Stress Secondary Brain Damage Oxygen-glucose Deprivation And Reoxygenation (OGD-R) Rat Brain Endothelial Cell TJ Integrity Stress Fiber Formation In Vivo Models Mechanistic Relationships
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