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JoVE Journal Behavior
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
 

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Article DOI: 10.3791/53109-v • 06:55 min • December 2nd, 2015
December 2nd, 2015 •
1, 1, 1, 2
1Department of Physiology and Pharmacology, West Virginia University Health Sciences Center, 2Division of Vascular and Endovascular Surgery, Center for Cardiovascular and Respiratory Sciences, West Virginia University Health Sciences Center

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The unpredictable chronic mild stress (UCMS) protocol is a validated method for studying behavioral and physiological changes associated with chronic stress and depressive symptoms. Eight weeks of imposition of the UCMS protocol induces behavioral changes and poor health outcomes in rodents of either gender.

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Unpredictable Chronic Mild Stress Depressive Symptoms Behavioral Changes Negative Health Outcomes Rodents Preclinical Model Stress-induced Depression Anhedonia Grooming Behavior Learned Helplessness Physiological Changes Neurological Changes Hypercortisolemia Hypertension Ameliorated Through Chronic Treatment SSRIs Acute Stress Protocols Extreme Stressors Randomized Exposures Damp Bedding Removal Of Bedding Cage Tilt Alteration Of Light/dark Cycles Social Stresses Shallow Water Bath Predator Sounds/smells Significant Behavioral Changes Cardiovascular System
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