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El Enfoque del ratón Ronda-ventana para ototóxicos Agente de entrega: Una rápida y técnica fiable para la inducción de degeneración de las células cocleares
JoVE Journal
Medicina
This content is Free Access.
JoVE Journal Medicina
The Mouse Round-window Approach for Ototoxic Agent Delivery: A Rapid and Reliable Technique for Inducing Cochlear Cell Degeneration
DOI:

12:21 min

November 26, 2015

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Capitoli

  • 00:05Titolo
  • 02:10Surgical Preparation and Positioning
  • 05:09Surgical Procedure
  • 08:07Round Window Application of Ototoxic Agent
  • 09:52Results: Targeted Cochlear Damage After Heptanol Exposure
  • 11:18Conclusion

Summary

Traduzione automatica

Various methods exist for introducing ototoxic agents to the cochleae of animal models. Presented is a surgical protocol for delivery of ototoxic agents to the round window niche. The procedure is reliable, creates targeted intra-cochlear lesions, and avoids mechanical damage to the microarchitecture. Examination of cochlear self-repair/regeneration is possible.

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