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Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
 

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Article DOI: 10.3791/53196-v • 07:36 min • November 20th, 2015
November 20th, 2015 •
1,2, 3, 1, 3, 3,4
1Department of Pediatrics, University of New Mexico, 2Department of Neurosciences, University of New Mexico, 3Department of Neurosurgery, Boston Children's Hospital, 4Department of Neurology, Harvard Medical School

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Encephalopathy of prematurity encompasses the central nervous system abnormalities associated with injury from preterm birth. This report describes a clinically relevant rat model of in utero transient systemic hypoxia-ischemia and intra-amniotic lipopolysaccharide administration (LPS) that mimics chorioamnionitis, and the related impact of infectious stimuli and placental underperfusion on CNS development.

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Modeling Encephalopathy Of Prematurity Prenatal Hypoxia-ischemia Intra-amniotic Lipopolysaccharide Rats CNS Abnormalities Preterm Birth Translational Objectives Therapeutic Strategies Brain Injury Preclinical Models Maternal-placental-fetal System Functional Deficits Pathophysiology Systemic Placental Perfusion Defects Placental Underperfusion Chorioamnionitis Pathogen-induced Inflammation Transient Systemic Hypoxia-ischemia Uterine Artery Occlusion Embryonic Day 18 (E18) CNS Damage White Matter Abnormalities Gait Abnormalities Imaging Abnormalities
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