Waiting
Elaborazione accesso...

Trial ends in Request Full Access Tell Your Colleague About Jove
Journal / Biology / Validation of a Mouse Model to Disrupt LINC…
JoVE Journal
Biology

È necessario avere un abbonamento a JoVE per visualizzare questo Contenuto. Accedi o inizia la tua prova gratuita.

JoVE Journal Biology
Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner
 

Validation of a Mouse Model to Disrupt LINC Complexes in a Cell-specific Manner

Article DOI: 10.3791/53318-v • 09:02 min • December 10th, 2015
December 10th, 2015 •
1, 1, 1
1Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine

Capitoli

Riepilogo
Automatic Translation

Nuclear envelope proteins play a central role in many basic biological processes and have been implicated in a variety of human diseases. This protocol describes a new Cre/Lox-based mouse model that allows for the spatiotemporal control of LINC complexes disruption.

Tags

Keywords: LINC Complexes Nuclear Migration Nuclear Anchorage Sun Proteins Nesprins Dominant-negative Transgenic Mouse Cre/Lox System Cell-type Specific Disruption
Read Article

Get cutting-edge science videos from JoVE sent straight to your inbox every month.

Waiting X
Simple Hit Counter