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Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration
 

Myocardial Infarction in Neonatal Mice, A Model of Cardiac Regeneration

Article DOI: 10.3791/54100-v • 07:48 min • May 24th, 2016
May 24th, 2016 •
1, 1, 1, 1
1Department of Physiology and Pharmacology, Western University

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This protocol describes a highly reproducible model of cardiac regeneration by surgical induction of myocardial infarction in the left ventricle of postnatal day 1 mice. The method involves induction of hypothermic anesthesia and ligation of the left anterior descending coronary artery.

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Keywords: Myocardial Infarction Neonatal Mice Cardiac Regeneration Left Anterior Descending Coronary Artery LAD Ligation Echocardiography Thoracotomy Suture Ischemia Nylon Sutures Anesthesia Maternal Rejection
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