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Pre-clinical Orthotopic Murine Model of Human Prostate Cancer
 

Pre-clinical Orthotopic Murine Model of Human Prostate Cancer

Article DOI: 10.3791/54125-v • 07:01 min • August 29th, 2016
August 29th, 2016 •
1, 1, 1, 2, 1, 1, 1, 1, 1, 1, 1, 1, 1, 1
1Department of Urology, VA Medical Center and UCSF, 2California Pacific Medical Center Research Institute

Capitoli

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Prostate cancer is the second most common cause of cancer-related deaths in the United States. An orthotopic cancer model provides a useful approach to understand the biology of prostate cancer and to evaluate the efficacy of therapeutic regimens. This protocol describes detailed steps necessary to establish an orthotopic prostate cancer mouse model.

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Keywords: Orthotopic Murine Prostate Cancer Xenograft Model Metastatic Cascade Primary Tumor Development Pre-clinical Evaluation Therapeutic Approaches Metastasis Molecular Mechanisms Trypan Blue Exclusion Basement Membrane-like Extracellular Matrix Immunocompromised Male Mice Surgical Procedure Povidone Iodine Ethanol
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