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Neurodegenerative Erkrankungen im Tiermodell der chronischen Amyloid-beta-Oligomers Infusion wird durch Antikörper-Behandlung Angereichert mit osmotische Pumpen entgegen gewirkt
JoVE Journal
Medicina
This content is Free Access.
JoVE Journal Medicina
Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
DOI:

10:19 min

August 14, 2016

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Capitoli

  • 00:05Titolo
  • 00:51Implantation of Cannula
  • 04:32Osmotic Pump Installation
  • 05:47Aβo Infusion in Awake and Freely Moving Rats
  • 08:43Results: Neuronal Loss Induced by Aβo Deposition is Attenuated by 6E10 Antibody Treatment
  • 09:23Conclusion

Summary

Traduzione automatica

To study the effects of Aβo in vivo, we developed a model based on repeated hippocampal infusions of soluble Aβo coupled with continuous infusion of Aβo antibody (6E10) in the hippocampus using osmotic pumps to counteract the neurotoxic effect of Aβo.

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