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Journal / Medicine / Neurodegeneration in an Animal Model of Chronic…
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JoVE Journal Medicine
Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps
 

Neurodegeneration in an Animal Model of Chronic Amyloid-beta Oligomer Infusion Is Counteracted by Antibody Treatment Infused with Osmotic Pumps

Article DOI: 10.3791/54215-v • 10:19 min • August 14th, 2016
August 14th, 2016 •
1,3, 3, 2, 1,3
1Department of Pharmacology, Université de Montréal, 2Department of Neuroscience, Université de Montréal, 3Hôpital du Sacré-coeur de Montréal Research Center, Université de Montréal

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To study the effects of Aβo in vivo, we developed a model based on repeated hippocampal infusions of soluble Aβo coupled with continuous infusion of Aβo antibody (6E10) in the hippocampus using osmotic pumps to counteract the neurotoxic effect of Aβo.

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Neurodegeneration Animal Model Chronic Amyloid-beta Oligomer Infusion Antibody Treatment Osmotic Pumps Surgical Intervention Alzheimer's Disease Therapies Neurotoxic Effect Immunotherapy Cannula Implantation PE50 Catheters Artificial Cerebrospinal Fluid Dental Cement Anesthesia Non-steroidal Anti-inflammatory Drug Shaving The Head Disinfect The Skin Veterinary Ophthalmic Ointment Stereot
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