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制备及<em>体外</em>磁共振成像基于树状大分子造影剂的表征

JoVE Journal
Chimica

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JoVE Journal Chimica

Preparation and In Vitro Characterization of Dendrimer-based Contrast Agents for Magnetic Resonance Imaging

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制备及<em>体外</em>磁共振成像基于树状大分子造影剂的表征

DOI:

10.3791/54776-v

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11:27 min

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December 04, 2016

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Serhat Gündüz, Tanja Savić, Đorđe Toljić, Goran Angelovski

¹MR Neuroimaging Agents,Max Planck Institute for Biological Cybernetics

Capitoli

00:05Titolo
01:10Preparation of the DOTA-type Macrocycle Monomer
03:05Preparation of the Dendrimeric Chelator
04:55Preparation of the Gd(III) Dendrimeric Constrast Agent (DCA)
06:28In Vitro Characterization of a Dendrimeric Contrast Agent (DCA) and Monomeric Analogue (GdDOTA)
09:09Results: Dendrimeric Contrast Agent Activity
10:38Conclusion

Summary

Traduzione automatica

本协议描述携带CYCLEN基于大环螯合物协调顺钆离子树枝状磁共振成像（MRI）造影剂的制备和表征。在一系列的体外 MRI实验中，相对于可商购的单体类似物时此代理产生的放大的磁共振信号。

Tags

Keywords: Dendrimer Magnetic Resonance Imaging Contrast Agent Paramagnetic Chelating DO3A Tert-butyl-2-bromo-4-nitrophenyl Butatnoate Palladium On Activated Carbon Hydrogenation Thiophosgene DOTA-type Monomer

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