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Murine Aortic Crush Injury
 

Murine Aortic Crush Injury: An Efficient In Vivo Model of Smooth Muscle Cell Proliferation and Endothelial Function

Article DOI: 10.3791/55201-v • 06:14 min • June 11th, 2017
June 11th, 2017 •
1,4, 2, 2,3,4, 2,3,4, 1,2,4
1Department of Surgery, Baltimore Veterans Affairs Medical Center, 2Department of Surgery, University of Maryland School of Medicine, 3Department of Physiology, University of Maryland School of Medicine, 4Center for Vascular and Inflammatory Diseases, University of Maryland School of Medicine

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Restenosis following cardiovascular procedures (bypass surgery, angioplasty, or stenting) is a significant problem reducing the durability of these procedures. An ideal therapy would inhibit smooth muscle cell (VSMC) proliferation while promoting regeneration of the endothelium. We describe a model for simultaneous assessment of VSMC proliferation and endothelial function in vivo.

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Keywords: Murine Aortic Crush Injury Vascular Smooth Muscle Cell Proliferation Reendothelialization Restenosis Vascular Biology In Vivo Model C57BL/6 Mouse Anesthesia Laparotomy Aorta Crush Tissue Analysis Evans Blue Dye Endothelial Function
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