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Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice
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Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

Bioluminescence and Near-infrared Imaging of Optic Neuritis and Brain Inflammation in the EAE Model of Multiple Sclerosis in Mice

DOI:
10.3791/55321-v

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08:05 min

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March 01, 2017

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,
1Institute of Clinical Pharmacology,University Hospital Frankfurt

Capitoli

  • 00:05Titolo
  • 00:54Immunization
  • 01:50EAE Course and Time of Imaging
  • 02:35Bioluminescent and Near-infrared Imaging of Optic Neuritis and Brain Inflammation
  • 03:41Image Analyses
  • 06:17Results: Time Course of Bioluminescence of Optic Neuritis and Assessment of Treatment Efficacy
  • 07:10Conclusion

Summary

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We show a technique for in vivo live bioluminescence and near-infrared imaging of optic neuritis and encephalitis in the experimental autoimmune encephalomyelitis (EAE) model for multiple sclerosis in SJL/J mice.

Tags

Keywords: BioluminescenceNear-infrared ImagingOptic NeuritisBrain InflammationEAE ModelMultiple SclerosisMiceNeuroimmunologyTherapyPTXPLP/CFACFAClinical SymptomsIn Vivo ImagingIsoflurane Anesthesia

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