Rivista
/
Medicina
/
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System
JoVE Journal
Medicina
This content is Free Access.
JoVE Journal Medicina
Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

Dry Powder and Nebulized Aerosol Inhalation of Pharmaceuticals Delivered to Mice Using a Nose-only Exposure System

DOI:
10.3791/55454-v

•

07:28 min

•

April 06, 2017

•

, ,
1Inflammation Research,Amgen

Capitoli

  • 00:05Titolo
  • 00:57Dry Powder and Nebulized Liquid Aerosol Generation
  • 02:46Aerosol Exposure Experimental Setup and Delivery
  • 05:28Results: Representative Effects of Real Time Aerosol Delivery
  • 06:51Conclusion

Summary

Traduzione automatica

Traduzione automatica

The inhalation unit described herein can generate, sample for characterization, and uniformly deposit a drug aerosol in the lungs of rodents. This enables the pre-clinical determination of the efficacy and safety of drug doses deposited in the lungs; key data enabling clinical inhaled drug development.

Tags

Dry PowderNebulized AerosolInhalationPharmaceuticalsMiceNose-only Exposure SystemAerosol GenerationJet MillMicronized ParticlesWright Dust FeedDry Powder Aerosol GeneratorNebulized Liquid AerosolSyringe PumpJet NebulizerPre-separatorAbsolute Filter Holder

Article

Embed

AGGIUNGI ALLA PLAYLIST

Usage Statistics

Video correlati

check_url/it/55454?article_type=v

Endotracheal Intubation in Mice via Direct Laryngoscopy Using an Otoscope
check_url/it/55454?article_type=v

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
check_url/it/55454?article_type=v

Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles
check_url/it/55454?article_type=v

Comparing the Effects of Electronic Cigarette Vapor and Cigarette Smoke in a Novel In Vivo Exposure System
check_url/it/55454?article_type=v

Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
check_url/it/55454?article_type=v

Contractions of Human-iPSC-derived Cardiomyocyte Syncytia Measured with a Ca-sensitive Fluorescent Dye in Temperature-controlled 384-well Plates
check_url/it/55454?article_type=v

A Rabbit Model of Aqueous-Deficient Dry Eye Disease Induced by Concanavalin A Injection into the Lacrimal Glands: Application to Drug Efficacy Studies
check_url/it/55454?article_type=v

Establishment of a Severe Dry Eye Model Using Complete Dacryoadenectomy in Rabbits
check_url/it/55454?article_type=v

Intratracheal Administration of Dry Powder Formulation in Mice
check_url/it/55454?article_type=v

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Read Article