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Neuroscience

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JoVE Journal Neuroscience
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
 

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Article DOI: 10.3791/55864-v • 07:51 min • June 18th, 2018
June 18th, 2018 •
*1,2,3, *1,4,5, 1,6, 1,6, 1,6, 1,6, 1,3,4
1Center for Addiction Research, University of Texas Medical Branch, 2Institute for Translational Sciences, University of Texas Medical Branch, 3Mitchell Center for Neurodegenerative Diseases, University of Texas Medical Branch, 4Department of Neurology, University of Texas Medical Branch, 5Department of Pathology, University of Texas Medical Branch, 6Department of Pharmacology and Toxicology, University of Texas Medical Branch
* These authors contributed equally

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Cue reactivity is conceptualized as sensitivity to cues linked with drug-taking experiences that contribute to craving and relapse in abstinent humans. Cue reactivity is modeled in rats by measuring attentional orientation toward drug-associated cues that results in appetitive approach behavior in a cue reactivity test following self-administration and forced abstinence.

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Protocol Measuring Cue Reactivity Rat Model Cocaine Use Disorder Motivation Seek Cocaine Self-administration Relapse Risk Pre-clinical Pharmacotherapies Genetic Factors Environmental Factors Operant Task Drug-seeking Behavior Sprague Dawley Rats Acclimation Period Jugular Vein Catheters Saline Treatment Group Cocaine Treatment Group Training Program
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