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JoVE Journal Neuroscience
Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice
 

Intracerebroventricular Treatment with Resiniferatoxin and Pain Tests in Mice

Article DOI: 10.3791/57570-v • 06:04 min • September 2nd, 2020
September 2nd, 2020 •
1,2, 1, 1,2
1Laboratory of Clinical Pharmacy and Pharmacology, Musashino University, 2Research Institute of Pharmaceutical Sciences, Musashino University

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The transient receptor potential vanilloid type 1 (TRPV1) in the supraspinal region has been suggested to play some roles in the brain function. Described here is a protocol for intracerebroventricular injection of resiniferatoxin for supraspinal TRPV1 desensitization in mice. Procedures for some pain tests are also presented.

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Keywords: Intracerebroventricular Resiniferatoxin TRPV1 Desensitization Anesthesia Subcutaneous Injection Paw Withdrawal Tail Pressure Test Nociception Mouse Model Neuropharmalogical Research
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