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Chemistry

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Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials
 

Facile Protocol for the Synthesis of Self-assembling Polyamine-based Peptide Amphiphiles (PPAs) and Related Biomaterials

Article DOI: 10.3791/57908-v 08:55 min June 25th, 2018
June 25th, 2018

Capitoli

Riepilogo

The synthesis of polyamine-based peptide amphiphiles (PPAs) is a significant challenge due to the presence of multiple amine nitrogens, which requires judicious use of protecting groups to mask these reactive functionalities. In this paper, we describe a facile method for the preparation of these new class of self-assembling molecules.

Tags

Keywords: Polyamine-based Peptide Amphiphiles PPAs Biomaterials Protecting Groups Hybrid Peptide Amphiphiles 2-Chlorotrityl Chloride Resin Polyamine DDE Boc Anhydride Fmoc Protected Amino Acid HBTU DIPEA
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