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Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube (SWCNT)-delivered MALAT1 Antisense Oligos
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Capitoli
- 00:04Titolo
- 00:56Synthesis of Functionalized SWCNTs
- 01:53Conjugation of Anti-MALAT1 Gapmer DNA Flanked by 2′-O Modified RNAs to Functionalized SWCNT
- 02:54Tail Vein Injection of SWCNT-anti-MALAT1
- 04:14Evaluation of the Disease Progression
- 05:01Results: SWCNT-anti-MALAT1 Oligonucleotides Successfully Represses Multiple Myeloma Cell Growth
- 06:51Conclusion
This manuscript describes the synthesis of a single-wall carbon nanotube (SWCNT)-conjugated MALAT1 antisense gapmer DNA oligonucleotide (SWCNT-anti-MALAT1), which demonstrates the reliable delivery of the SWCNT and the potent therapeutic effect of anti-MALAT1 in vitro and in vivo. Methods used for synthesis, modification, conjugation, and injection of SWCNT-anti-MALAT1 are described.
