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Neuroscience

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JoVE Journal Neuroscience
Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea
 

Morphological and Functional Evaluation of Ribbon Synapses at Specific Frequency Regions of the Mouse Cochlea

Article DOI: 10.3791/59189-v • 09:54 min • May 10th, 2019
May 10th, 2019 •
*1, *1, 1, 1, 1, 1, 1, 2, 1, 1
1Department of Otolaryngology-Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, 2Department of Otology, Shengjing Hospital of China Medical University
* These authors contributed equally

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This manuscript describes an experimental protocol for evaluating the morphological characteristics and functional status of ribbon synapses in normal mice. The present model is also suitable for noise-induced and age-related cochlear synaptopathy-restricted models. The correlative results of previous mouse studies are also discussed.

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Keywords: Cochlea Frequency Region Synapse Neuropathy Hearing Loss Tinnitus Hyperacusis Auditory Brainstem Response ABR Cochlea Dissection Paraformaldehyde EDTA Microscopy
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