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使用左前部降冠动脉的永久结扎的月心肌梗死模型

JoVE Journal
Medicina

This content is Free Access.

JoVE Journal Medicina

Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery

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使用左前部降冠动脉的永久结扎的月心肌梗死模型

DOI:

10.3791/59591-v

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08:38 min

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August 16, 2019

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Jérôme Lugrin², Roumen Parapanov², Thorsten Krueger, Lucas Liaudet

¹Service of Adult Intensive Care Medicine, Department of Interdisciplinary Centers and Logistics, Lausanne University Hospital and Faculty of Biology and Medicine,Lausanne University, ²Service of Thoracic Surgery, Department of Surgery and Anesthesiology Services, Lausanne University Hospital and Faculty of Biology and Medicine,Lausanne University

Capitoli

00:04Titolo
00:55Tracheal Cannulation
03:30Left Anterior Descending (LAD) Coronary Artery Ligation
05:48Post-Operative Procedures
06:45Results: Representative Fibrosis and Inflammation in Day 7 Whole Myocardium Extracts
08:05Conclusion

Summary

Traduzione automatica

在这里，我们描述了一个外科手术，演示如何实现小鼠左前下降冠状动脉的永久结扎。该模型对研究心肌梗死的病理生理学和伴随的生物过程具有十分相关的意义。

Tags

Murine Myocardial Infarction Model Permanent Ligation Left Anterior Descending Coronary Artery Cardiac Biology Cardiac Physiology Surgical Procedure Anesthetized Mouse Ventilator Tracheal Intubation Thoracotomy Coronary Artery Ligation

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