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Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery
JoVE Journal
Medicine
This content is Free Access.
JoVE Journal Medicine
Murine Myocardial Infarction Model using Permanent Ligation of Left Anterior Descending Coronary Artery
DOI:

08:38 min

August 16, 2019

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Chapters

  • 00:04Title
  • 00:55Tracheal Cannulation
  • 03:30Left Anterior Descending (LAD) Coronary Artery Ligation
  • 05:48Post-Operative Procedures
  • 06:45Results: Representative Fibrosis and Inflammation in Day 7 Whole Myocardium Extracts
  • 08:05Conclusion

Summary

Automatic Translation

Herein we describe a surgical procedure showing how to achieve permanent ligation of the left-anterior descending coronary artery in mice. This model is of high relevance to investigate the pathophysiology of myocardial infarction and the concomitant biological processes.

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