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Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
 

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Article DOI: 10.3791/59688-v • 08:41 min • June 3rd, 2019
June 3rd, 2019 •
1, 1, 1, 1, 1, 1, 1, 1
1The State Key Laboratory of Pharmaceutical Biotechnology and the Department of Pharmacology and Pharmacy, University of Hong Kong

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The protocol describes the use of wire myography to evaluate the transmural isometric tension of mesenteric arteries isolated from mice, with special consideration of the modulation by factors released from endothelial cells and perivascular adipose tissues.

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Keywords: Vascular Tone Mesenteric Arteries Perivascular Adipose Tissues Isometric Condition Vascular Responsiveness Adipose Tissue Dysfunction Hypertension Cardiovascular Complications Myograph Normalization Passive Stretch Wall Tension Active Force Potassium Chloride
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