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Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents
 

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Article DOI: 10.3791/60036-v • 07:34 min • July 14th, 2021
July 14th, 2021 •
*1, *1, 1, 1
1Unidade de Investigação Cardiovascular, Departamento de Cirurgia e Fisiologia, Faculdade de Medicina, Universidade do Porto
* These authors contributed equally

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Here we describe a step-by-step protocol of surgical aorta debanding in the well-established mice model of aortic-constriction. This procedure not only allows studying the mechanisms underlying the left ventricular reverse remodeling and regression of hypertrophy but also to test novel therapeutic options that might accelerate myocardial recovery.

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Keywords: Left Ventricular Reverse Remodeling Aortic Debanding Rodents Myocardial Reverse Remodeling Cardiomyocytes Regression Isometric Functional Recovery Pressure Overload Aortic Stenosis Mechanical Ventilation Analgesia Aortic Banding Aortic Debanding Tissue Dissection
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