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Journal / Developmental Biology / Reprogramación hemogénica de fibroblastos humanos …
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Developmental Biology

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JoVE Journal Developmental Biology
Reprogramación hemogénica de fibroblastos humanos por expresión forzada de factores de transcripción
 
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Reprogramación hemogénica de fibroblastos humanos por expresión forzada de factores de transcripción

Article DOI: 10.3791/60112-v • 11:42 min • November 4th, 2019
November 4th, 2019 •
1,2,3, 3, 4, 5,6, 1,2,3
1Molecular Medicine and Gene Therapy, Lund Stem Cell Center, Lund University, 2Wallenberg Center for Molecular, Lund University, 3Center for Neuroscience and Cell Biology, University of Coimbra, 4Skolkovo Institute of Science and Technology, 5Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, 6Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai

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Este protocolo demuestra la inducción de un programa hemogénico en fibroblastos dérmicos humanos mediante la expresión forzada de los factores de transcripción GATA2, GFI1B y FOS para generar células hematopoyéticas madre y progenitoras.

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Developmental Biology Número 153 reprogramación hemogénica fibroblastos factores de transcripción hematopoyesis células hematopoyéticas transición endotelial a hematopoyética
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