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Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow
 

Hemocompatibility Testing of Blood-Contacting Implants in a Flow Loop Model Mimicking Human Blood Flow

Article DOI: 10.3791/60610-v • 09:41 min • March 5th, 2020
March 5th, 2020 •
1, 2,3, 4, 4, 4, 1, 1, 1, 1
1Department of Thoracic, Cardiac and Vascular Surgery, University Hospital Tuebingen, 2Acandis GmbH, 3Institute of Biomedical Engineering, University of Stuttgart, 4Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic

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This protocol describes a comprehensive hemocompatibility evaluation of blood-contacting devices using laser-cut neurovascular implants. A flow loop model with fresh, heparinized human blood is applied to mimic blood flow. After perfusion, various hematologic markers are analyzed and compared to the values gained directly after blood collection for hemocompatibility evaluation of the tested devices.

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Keywords: Hemocompatibility Testing Blood-contacting Implants Flow Loop Human Blood Flow International Standard Organization Thrombotic Events Anticoagulants Biomaterial Research Heparin Loading Neurovascular Laser Cut Implant Peristaltic Pump Whole Blood Count Analysis EDTA
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