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Genetics

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JoVE Journal Genetics
A Screening Method for Identification of Heterochromatin-Promoting Drugs Using Drosophila
 

A Screening Method for Identification of Heterochromatin-Promoting Drugs Using Drosophila

Article DOI: 10.3791/60917-v • 06:22 min • March 12th, 2020
March 12th, 2020 •
1, 1, 1, 1, 1, 1, 1
1Department of Medicine, University of California San Diego

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Drosophila is a widely used experimental model suitable for screening drugs with potential applications for cancer therapy. Here, we describe the use of Drosophila variegated eye color phenotypes as a method for screening small-molecule compounds that promote heterochromatin formation.

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Heterochromatin-promoting Drugs Screening Method Drosophila Compound Identification Cancer Therapy Variegated Eye Color Phenotype Drug Library Solvent Concentration Male Flies Virgin Female Flies Food Vial Drosophila Food Medium
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