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小鼠干粉配方的内经管理
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JoVE Journal Medicina
Intratracheal Administration of Dry Powder Formulation in Mice
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小鼠干粉配方的内经管理

DOI:
10.3791/61469-v

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07:55 min

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July 25, 2020

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, , ,
1Department of Pharmacology and Pharmacy, LKS Faculty of Medicine,The University of Hong Kong, 2Advanced Drug Delivery Group, Sydney Pharmacy School, Faculty of Medicine and Health,The University of Sydney

Capitoli

  • 00:04Introduction
  • 01:22Fabrication of Dry Powder Insufflator and Loading of Dry Powder
  • 02:36Intubation
  • 04:17Powder Administration
  • 05:25Results: Optimization of Intratracheal Administration of mRNA Formulation
  • 07:23Conclusion

Summary

Traduzione automatica

Traduzione automatica

吸入干粉配方在治疗呼吸系统疾病方面有很大的潜力。在进入人类研究之前，有必要在前科研究中评估干粉配方的功效。提出了一种简单而非侵入性的方法，通过体外路线对小鼠的干粉进行管理。

Tags

Intratracheal AdministrationDry Powder FormulationMiceInsufflatorPulmonary AbsorptionBioavailabilityTherapeutic EffectsPre-clinical Animal ModelsIntubationStatic ChargesGel Loading Pipette TipWeighing PaperSyringeAnesthesiaBALB/c MouseOptical FiberGuiding Cannula

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