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Neuroscience

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JoVE Journal Neuroscience
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
 

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Article DOI: 10.3791/61504-v • 07:21 min • May 27th, 2022
May 27th, 2022 •
*1, *2,3, 1,3, *1,2,3, *1,4,5
1Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 2George W. Woodruff School of Mechanical Engineering, Georgia Institute of Technology, 3Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 4Department of Pediatrics, Emory University School of Medicine, 5Children's Research Scholar, Children's Healthcare of Atlanta
* These authors contributed equally

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This protocol presents methods to characterize the neuroinflammatory and hemodynamic response to mild traumatic brain injury and to integrate these data as part of a multivariate systems analysis using partial least squares regression.

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Systems Analysis Neuroinflammatory Response Hemodynamic Response Traumatic Brain Injury Multivariate System Analysis Partial Least Squares Regression Injury Induction Response Confirmation Mouse Positioning Impact Procedure Tissue Securing Head Acceleration Recovery Period DCS Sensor Placement Data Acquisition
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