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Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
 

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Article DOI: 10.3791/61547-v • 06:35 min • June 28th, 2021
June 28th, 2021 •
*1, *1, *1, *1, *1
1Discipline of Clinical Emergencies, Department of Clinical Medicine, HCFMUSP / LIM 51, University of São Paulo Medical School
* These authors contributed equally

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Animal models for severe acute pancreatitis enable the study of pathophysiological changes at the initial stage, facilitating observation of the evolution of inflammatory events. Here we provide a protocol for the induction of severe acute biliary pancreatitis by retrograde infusion of sodium taurocholate into the pancreatic duct of anesthetized C57BL/6 mice.

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Keywords: Acute Pancreatitis C57BL/6 Mice Sodium Taurocholate Biliary Pancreatitis Inflammatory Response Pharmacological Intervention Laparotomy Common Bile Duct Duodenum Infusion Animal Model
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