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纤维蛋白富集和 tPA 敏感的光血栓形成卒中模型
JoVE Journal
Neuroscienze
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JoVE Journal Neuroscienze
A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model
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纤维蛋白富集和 tPA 敏感的光血栓形成卒中模型

DOI:
10.3791/61740-v

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09:42 min

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June 04, 2021

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, ,
1Department of Anesthesiology, Taipei Veterans General Hospital,National Yang-Ming University School of Medicine, 2Department of Neuroscience, Center for Brain Immunology and Glia (BIG),University of Virginia School of Medicine

Capitoli

  • 00:04Introduction
  • 01:19Ligation of the Ipsilateral Common Carotid Artery
  • 02:35Skull Thinning Above the Middle Cranial Artery Branch and Photoactivation
  • 04:44Intravital Imaging and tPA Administration
  • 06:34Results: Immunofluorescence Labeling, Intravital Imaging, and the Effects of tPA Treatment on CBF Recovery and Infarct Size
  • 08:50Conclusion

Summary

Traduzione automatica

Traduzione automatica

传统的光血栓中风 （PTS） 模型主要诱导对组织纤溶酶原激活剂 （tPA） 溶解治疗具有高耐药性的致密血小板聚集体。本文通过共注射凝血酶和光敏染料进行光活化，引入了改良的小鼠PTS模型。凝血酶增强的 PTS 模型产生混合血小板：纤维蛋白凝块，并且对 tPA 溶栓高度敏感。

Tags

Keywords: Photothrombotic Stroke ModelFibrin-enrichedTPA-sensitiveThrombolytic TherapyBlood ClotAcute Stroke PatientPreclinical Stroke ResearchThrombolytic Therapies

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