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A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
 

A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion

Article DOI: 10.3791/62080-v • 06:44 min • February 28th, 2021
February 28th, 2021 •
*1, *1, 2, 1,2, 1, 1,2
1Department of Surgery, Medical University of South Carolina, 2Ralph H. Johnson Veterans Affairs Medical Center
* These authors contributed equally

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Chronic pancreatitis (CP) is a disease characterized by inflammation and fibrosis of the pancreas, often associated with intractable abdominal pain. This article focuses on refining the technique to generate a mouse model of CP via bile duct infusion with 2,4,6 -trinitrobenzene sulfonic acid (TNBS).

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Keywords: Mouse Model Chronic Pancreatitis Bile Duct TNBS Infusion Neuropathic Pain Von Frey Monofilaments TNBS Solution Pancreatic Duct Abdominal Pain Fibrosis Inflammation
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