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Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
JoVE Journal
Medicina
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JoVE Journal Medicina
Advanced Cardiac Rhythm Management by Applying Optogenetic Multi-Site Photostimulation in Murine Hearts
DOI:

08:43 min

August 26, 2021

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Capitoli

  • 00:04Introduction
  • 00:54Langendorff Perfusion
  • 02:53Arrhythmia Induction and Optical Defibrillation
  • 04:41Optical Mapping
  • 05:45Results: Analysis of Success Rates and Manipulation of Cardiac Rhythm by Means of Photosimulation
  • 07:56Conclusion

Summary

Traduzione automatica

This work reports a method for controlling the cardiac rhythm of intact murine hearts of transgenic channelrhodopsin-2 (ChR2) mice using local photostimulation with a micro-LED array and simultaneous optical mapping of epicardial membrane potential.

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