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Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis
 

Destabilization of the Medial Meniscus and Cartilage Scratch Murine Model of Accelerated Osteoarthritis

Article DOI: 10.3791/64159-v • 07:06 min • July 6th, 2022
July 6th, 2022 •
1, 1, 1, 2, 2
1Institute of Biomedical and Environmental Health Research, University of the West of Scotland, 2Institute of Infection, Immunity and Inflammation, University of Glasgow

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The present protocol describes the controlled microblade scratches on the surface of the articular cartilage after destabilizing the mouse knee by cutting the medial miniscotibial ligament. This animal model presents an accelerated form of osteoarthritis (OA) suitable for studying osteophyte formation, osteosclerosis, and early-stage pain.

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Destabilization Medial Meniscus Cartilage Scratch Murine Model Accelerated Osteoarthritis Post-traumatic Osteoarthritis Therapies Osteophyte Formation Load Changes Pain Indication Endochondral Ossification Injury-driven Pain Medial Meniscotibial Ligament Cutting Cadavers Surgery Sterile Room Sterile Instruments Sterile Drapes Mouse Weighing Fur Clipping Skin Disinfection Analgesia Administration
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