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Bioengineering

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JoVE Journal Bioengineering
Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization
 

Cellular Affinity of Particle-Stabilized Emulsion to Boost Antigen Internalization

Article DOI: 10.3791/64406-v • 10:06 min • September 2nd, 2022
September 2nd, 2022 •
*1,2,3, *3,4, 3,4, 3, 1,2
1Graduate School of Bio-Applications and Systems Engineering, Tokyo University of Agriculture and Technology, 2Institute of Global Innovation Research, Tokyo University of Agriculture and Technology, 3State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, 4University of Chinese Academy of Sciences
* These authors contributed equally

Capitoli

Riepilogo
Automatic Translation

To rationally design efficient adjuvants, we developed poly-lactic-co-glycolic acid nanoparticle-stabilized Pickering emulsion (PNPE). The PNPE possessed unique softness and a hydrophobic interface for potent cellular contact and offered high-content antigen loading, improving the cellular affinity of the delivery system to antigen-presenting cells and inducing efficient internalization of antigens.

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Keywords: PLGA Nanoparticles Pickering Emulsion Cellular Affinity Antigen Internalization Vaccine Development Particle Size Zeta Potential
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