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Neuroscience

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JoVE Journal Neuroscience
Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms
 

Automated Multimodal Stimulation and Simultaneous Neuronal Recording from Multiple Small Organisms

Article DOI: 10.3791/65042-v • 08:28 min • March 3rd, 2023
March 3rd, 2023 •
1,2, 1, 1, 1, 1,3
1Department of Biomedical Engineering, Worcester Polytechnic Institute, 2Graduate School of Biomedical Sciences, UMass Chan Medical School, 3Department of Biology and Biotechnology, Worcester Polytechnic Institute

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We present a method for the flexible chemical and multimodal stimulation and recording of simultaneous neural activity from many Caenorhabditis elegans worms. This method uses microfluidics, open-source hardware and software, and supervised automated data analysis to enable the measurement of neuronal phenomena such as adaptation, temporal inhibition, and stimulus crosstalk.

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Keywords: Automated Stimulation Multimodal Stimulation Simultaneous Neuronal Recording Multiple Small Organisms Neural Responses Brain Activity Repeatability Neuronal Variability Adaptation Sensory Integration Microfluidic Device Worm Loading Neural Phenomena
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