Arshad Desai Ludwig Institute for Cancer Research, San Diego Biography Publications Institution JoVE Articles Arshad Desai has not added a biography. If you are Arshad Desai and would like to personalize this page please email our Author Liaison for assistance. Publications Ancestral Roles of the Fam20C Family of Secreted Protein Kinases Revealed in The Journal of Cell Biology. Sep, 2019 | Pubmed ID: 31541016 Pharmacological Convergence Reveals a Lipid Pathway That Regulates C. Elegans Lifespan Nature Chemical Biology. 05, 2019 | Pubmed ID: 30911178 A High-content Imaging Approach to Profile Embryonic Development Development (Cambridge, England). Apr, 2019 | Pubmed ID: 30890570 The Kinetochore-Microtubule Coupling Machinery Is Repurposed in Sensory Nervous System Morphogenesis Developmental Cell. 03, 2019 | Pubmed ID: 30827898 CFI-400945 is Not a Selective Cellular PLK4 Inhibitor Proceedings of the National Academy of Sciences of the United States of America. 11, 2018 | Pubmed ID: 30377272 Promoting an "Auteur Theory" for Young Scientists: Preserving Excitement and Creativity … BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology. 11, 2018 | Pubmed ID: 30238592 CYK-4 Functions Independently of Its Centralspindlin Partner ZEN-4 to Cellularize Oocytes in Germline Syncytia ELife. 07, 2018 | Pubmed ID: 29989548 A Positive-feedback-based Mechanism for Constriction Rate Acceleration During Cytokinesis in ELife. 07, 2018 | Pubmed ID: 29963981 Analyzing the Micromechanics of the Cell Division Apparatus Methods in Cell Biology. 2018 | Pubmed ID: 29957203 Employing the One-cell C. Elegans Embryo to Study Cell Division Processes Methods in Cell Biology. 2018 | Pubmed ID: 29804670 Cdc73 Suppresses Genome Instability by Mediating Telomere Homeostasis PLoS Genetics. 01, 2018 | Pubmed ID: 29320491 Meiosis: The Origins of Bias Current Biology : CB. 12, 2017 | Pubmed ID: 29257963 Taming the Beast: Control of APC/C-Dependent Destruction Cold Spring Harbor Symposia on Quantitative Biology. 2017 | Pubmed ID: 29133301 Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans Developmental Cell. 10, 2017 | Pubmed ID: 29065307 Kinetochores Accelerate or Delay APC/C Activation by Directing Cdc20 to Opposing Fates Genes & Development. 06, 2017 | Pubmed ID: 28698300 Chromosome Mis-segregation Generates Cell-Cycle-Arrested Cells with Complex Karyotypes That Are Eliminated by the Immune System Developmental Cell. 06, 2017 | Pubmed ID: 28633018 A Toolkit for GFP-mediated Tissue-specific Protein Degradation in Development (Cambridge, England). 07, 2017 | Pubmed ID: 28619826 Dephosphorylation of the Ndc80 Tail Stabilizes Kinetochore-Microtubule Attachments Via the Ska Complex Developmental Cell. 05, 2017 | Pubmed ID: 28535376 An Engineered Minimal Chromosomal Passenger Complex Reveals a Role for INCENP/Sli15 Spindle Association in Chromosome Biorientation The Journal of Cell Biology. 04, 2017 | Pubmed ID: 28314741 How Centrioles Acquire the Ability to Reproduce ELife. 03, 2017 | Pubmed ID: 28271993 A Molecular View of Kinetochore Assembly and Function Biology. Jan, 2017 | Pubmed ID: 28125021 A Nucleoporin Docks Protein Phosphatase 1 to Direct Meiotic Chromosome Segregation and Nuclear Assembly Developmental Cell. 09, 2016 | Pubmed ID: 27623381 53BP1 and USP28 Mediate P53 Activation and G1 Arrest After Centrosome Loss or Extended Mitotic Duration The Journal of Cell Biology. 07, 2016 | Pubmed ID: 27432897 A TOGgle for Tension at Kinetochores Cell. Jun, 2016 | Pubmed ID: 27259144 A Small RNA-Catalytic Argonaute Pathway Tunes Germline Transcript Levels to Ensure Embryonic Divisions Cell. Apr, 2016 | Pubmed ID: 27020753 A Cell Biologist's Field Guide to Aurora Kinase Inhibitors Frontiers in Oncology. 2015 | Pubmed ID: 26732741 NOCA-1 Functions with γ-tubulin and in Parallel to Patronin to Assemble Non-centrosomal Microtubule Arrays in C. Elegans ELife. Sep, 2015 | Pubmed ID: 26371552 Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation Cell Reports. Jul, 2015 | Pubmed ID: 26119738 Orthogonal Targeting of EGFRvIII Expressing Glioblastomas Through Simultaneous EGFR and PLK1 Inhibition Oncotarget. May, 2015 | Pubmed ID: 26059434 Kinetochore-localized BUB-1/BUB-3 Complex Promotes Anaphase Onset in C. Elegans The Journal of Cell Biology. May, 2015 | Pubmed ID: 25987605 Cell Biology. Reversible Centriole Depletion with an Inhibitor of Polo-like Kinase 4 Science (New York, N.Y.). Jun, 2015 | Pubmed ID: 25931445 Separase Cleaves the N-Tail of the CENP-A Related Protein CPAR-1 at the Meiosis I Metaphase-Anaphase Transition in C. Elegans PloS One. 2015 | Pubmed ID: 25919583 Preventing Farnesylation of the Dynein Adaptor Spindly Contributes to the Mitotic Defects Caused by Farnesyltransferase Inhibitors Molecular Biology of the Cell. May, 2015 | Pubmed ID: 25808490 The CENP-A N-tail Confers Epigenetic Stability to Centromeres Via the CENP-T Branch of the CCAN in Fission Yeast Current Biology : CB. Feb, 2015 | Pubmed ID: 25619765 The Outer Kinetochore Protein KNL-1 Contains a Defined Oligomerization Domain in Nematodes Molecular Biology of the Cell. Jan, 2015 | Pubmed ID: 25411336 A New Piece in the Kinetochore Jigsaw Puzzle The Journal of Cell Biology. Aug, 2014 | Pubmed ID: 25135931 PCNA and Msh2-Msh6 Activate an Mlh1-Pms1 Endonuclease Pathway Required for Exo1-independent Mismatch Repair Molecular Cell. Jul, 2014 | Pubmed ID: 24981171 Mlh2 is an Accessory Factor for DNA Mismatch Repair in Saccharomyces Cerevisiae PLoS Genetics. May, 2014 | Pubmed ID: 24811092 A Bub1-Mad1 Interaction Targets the Mad1-Mad2 Complex to Unattached Kinetochores to Initiate the Spindle Checkpoint The Journal of Cell Biology. Mar, 2014 | Pubmed ID: 24567362 Linked In: Formation and Regulation of Microtubule Attachments During Chromosome Segregation Current Opinion in Cell Biology. Feb, 2014 | Pubmed ID: 24529253 Spatial Control of Phospholipid Flux Restricts Endoplasmic Reticulum Sheet Formation to Allow Nuclear Envelope Breakdown Genes & Development. Jan, 2014 | Pubmed ID: 24449268 Meiotic Double-strand Breaks Uncover and Protect Against Mitotic Errors in the C. Elegans Germline Current Biology : CB. Dec, 2013 | Pubmed ID: 24239117 Crosstalk Between Microtubule Attachment Complexes Ensures Accurate Chromosome Segregation Science (New York, N.Y.). Dec, 2013 | Pubmed ID: 24231804 The Midbody Ring Scaffolds the Abscission Machinery in the Absence of Midbody Microtubules The Journal of Cell Biology. Nov, 2013 | Pubmed ID: 24217623 Dominant Mutations in S. Cerevisiae PMS1 Identify the Mlh1-Pms1 Endonuclease Active Site and an Exonuclease 1-Independent Mismatch Repair Pathway PLoS Genetics. Oct, 2013 | Pubmed ID: 24204293 A Conserved RhoGAP Limits M Phase Contractility and Coordinates with Microtubule Asters to Confine RhoA During Cytokinesis Developmental Cell. Sep, 2013 | Pubmed ID: 24012485 A Two-step Mechanism for Epigenetic Specification of Centromere Identity and Function Nature Cell Biology. Sep, 2013 | Pubmed ID: 23873148 Direct Binding of SAS-6 to ZYG-1 Recruits SAS-6 to the Mother Centriole for Cartwheel Assembly Developmental Cell. May, 2013 | Pubmed ID: 23673331 Tension Sensing by Aurora B Kinase is Independent of Survivin-based Centromere Localization Nature. May, 2013 | Pubmed ID: 23604256 What the Hec is Up with Mouse Oocyte Meiosis? Developmental Cell. Apr, 2013 | Pubmed ID: 23597481 Hierarchical Assembly of the Eggshell and Permeability Barrier in C. Elegans The Journal of Cell Biology. Aug, 2012 | Pubmed ID: 22908315 An Inverse Relationship to Germline Transcription Defines Centromeric Chromatin in C. Elegans Nature. Apr, 2012 | Pubmed ID: 22495302 Microtubule Binding by KNL-1 Contributes to Spindle Checkpoint Silencing at the Kinetochore The Journal of Cell Biology. Feb, 2012 | Pubmed ID: 22331849 Visualization of Eukaryotic DNA Mismatch Repair Reveals Distinct Recognition and Repair Intermediates Cell. Nov, 2011 | Pubmed ID: 22118461 Affinity Purification of Protein Complexes in C. Elegans Methods in Cell Biology. 2011 | Pubmed ID: 22118282 Rapid De Novo Centromere Formation Occurs Independently of Heterochromatin Protein 1 in C. Elegans Embryos Current Biology : CB. Nov, 2011 | Pubmed ID: 22018540 Acute Drug Treatment in the Early C. Elegans Embryo PloS One. 2011 | Pubmed ID: 21935434 Uncoordinated Loss of Chromatid Cohesion is a Common Outcome of Extended Metaphase Arrest PloS One. 2011 | Pubmed ID: 21829677 A High-resolution C. Elegans Essential Gene Network Based on Phenotypic Profiling of a Complex Tissue Cell. Apr, 2011 | Pubmed ID: 21529718 The Chromosomal Passenger Complex and Centralspindlin Independently Contribute to Contractile Ring Assembly The Journal of Cell Biology. Apr, 2011 | Pubmed ID: 21464231 A PSHaver for Centromeric Histones Molecular Cell. Nov, 2010 | Pubmed ID: 21070962 A Kinetochore-independent Mechanism Drives Anaphase Chromosome Separation During Acentrosomal Meiosis Nature Cell Biology. Sep, 2010 | Pubmed ID: 20729837 Removal of Spindly from Microtubule-attached Kinetochores Controls Spindle Checkpoint Silencing in Human Cells Genes & Development. May, 2010 | Pubmed ID: 20439434 Analyzing the Effects of Delaying Aster Separation on Furrow Formation During Cytokinesis in the Caenorhabditis Elegans Embryo Molecular Biology of the Cell. Jan, 2010 | Pubmed ID: 19889842 The Hydrolethalus Syndrome Protein HYLS-1 Links Core Centriole Structure to Cilia Formation Genes & Development. Sep, 2009 | Pubmed ID: 19656802 Structural Memory in the Contractile Ring Makes the Duration of Cytokinesis Independent of Cell Size Cell. May, 2009 | Pubmed ID: 19490897 Systematic Analysis in Caenorhabditis Elegans Reveals That the Spindle Checkpoint is Composed of Two Largely Independent Branches Molecular Biology of the Cell. Feb, 2009 | Pubmed ID: 19109417 A New Mechanism Controlling Kinetochore-microtubule Interactions Revealed by Comparison of Two Dynein-targeting Components: SPDL-1 and the Rod/Zwilch/Zw10 Complex Genes & Development. Sep, 2008 | Pubmed ID: 18765790 SAS-4 is Recruited to a Dynamic Structure in Newly Forming Centrioles That is Stabilized by the Gamma-tubulin-mediated Addition of Centriolar Microtubules The Journal of Cell Biology. Feb, 2008 | Pubmed ID: 18299348 The Wages of CIN The Journal of Cell Biology. Feb, 2008 | Pubmed ID: 18283117 Expression and Imaging of Fluorescent Proteins in the C. Elegans Gonad and Early Embryo Methods in Cell Biology. 2008 | Pubmed ID: 18155464 KNL1 and the CENP-H/I/K Complex Coordinately Direct Kinetochore Assembly in Vertebrates Molecular Biology of the Cell. Feb, 2008 | Pubmed ID: 18045986 A Role for Rab5 in Structuring the Endoplasmic Reticulum The Journal of Cell Biology. Jul, 2007 | Pubmed ID: 17591921 Functional Genomics Identifies a Myb Domain-containing Protein Family Required for Assembly of CENP-A Chromatin The Journal of Cell Biology. Mar, 2007 | Pubmed ID: 17339379 Centromere Identity Maintained by Nucleosomes Assembled with Histone H3 Containing the CENP-A Targeting Domain Molecular Cell. Jan, 2007 | Pubmed ID: 17244537 A Bir1-Sli15 Complex Connects Centromeres to Microtubules and is Required to Sense Kinetochore Tension Cell. Dec, 2006 | Pubmed ID: 17174893 An FHA Domain-mediated Protein Interaction Network of Rad53 Reveals Its Role in Polarized Cell Growth The Journal of Cell Biology. Dec, 2006 | Pubmed ID: 17130285 Molecular Analysis of Mitotic Chromosome Condensation Using a Quantitative Time-resolved Fluorescence Microscopy Assay Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17005720 The Human Mis12 Complex is Required for Kinetochore Assembly and Proper Chromosome Segregation The Journal of Cell Biology. Apr, 2006 | Pubmed ID: 16585270 Unstable Microtubule Capture at Kinetochores Depleted of the Centromere-associated Protein CENP-F The EMBO Journal. Nov, 2005 | Pubmed ID: 16252009 A Complex Containing the Sm Protein CAR-1 and the RNA Helicase CGH-1 is Required for Embryonic Cytokinesis in Caenorhabditis Elegans The Journal of Cell Biology. Oct, 2005 | Pubmed ID: 16247027 Microtubule Capture by CENP-E Silences BubR1-dependent Mitotic Checkpoint Signaling The Journal of Cell Biology. Sep, 2005 | Pubmed ID: 16144904 Distinct Roles for Two C. Elegans Anillins in the Gonad and Early Embryo Development (Cambridge, England). Jun, 2005 | Pubmed ID: 15930113 The CENP-F-like Proteins HCP-1 and HCP-2 Target CLASP to Kinetochores to Mediate Chromosome Segregation Current Biology : CB. Apr, 2005 | Pubmed ID: 15854912 Kinetochore-spindle Microtubule Interactions During Mitosis Current Opinion in Cell Biology. Feb, 2005 | Pubmed ID: 15661517 Centriole Assembly Requires Both Centriolar and Pericentriolar Material Proteins Developmental Cell. Dec, 2004 | Pubmed ID: 15572125 The Minus End in Sight Current Biology : CB. Aug, 2003 | Pubmed ID: 12906817 Een semi-High-throughput imaging methode en data visualisatie Toolkit om C. elegans embryonale ontwikkeling te analyseren Renat N. Khaliullin1,2,3, Jeffrey M. Hendel1,2, Adina Gerson-Gurwitz1,2, Shaohe Wang1,4,5, Stacy D. Ochoa1,6, Zhiling Zhao1,7, Arshad Desai1,2, Karen Oegema1,2, Rebecca A. Green1,2 1Ludwig Institute for Cancer Research, San Diego, 2Department of Cellular and Molecular Medicine, University of California, San Diego, 3Recursion Pharmaceuticals, 4Biomedical Sciences Graduate Program, University of California, San Diego, 5Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 6Department of Biology, San Diego State University, 7Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco JoVE 60362 발생학
Een semi-High-throughput imaging methode en data visualisatie Toolkit om C. elegans embryonale ontwikkeling te analyseren Renat N. Khaliullin1,2,3, Jeffrey M. Hendel1,2, Adina Gerson-Gurwitz1,2, Shaohe Wang1,4,5, Stacy D. Ochoa1,6, Zhiling Zhao1,7, Arshad Desai1,2, Karen Oegema1,2, Rebecca A. Green1,2 1Ludwig Institute for Cancer Research, San Diego, 2Department of Cellular and Molecular Medicine, University of California, San Diego, 3Recursion Pharmaceuticals, 4Biomedical Sciences Graduate Program, University of California, San Diego, 5Cell Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, 6Department of Biology, San Diego State University, 7Developmental and Stem Cell Biology Graduate Program, University of California, San Francisco JoVE 60362 발생학