Assaf Friedler Institute of Chemistry The Hebrew University of Jerusalem Biography Publications Institution JoVE Articles Assaf Friedler has not added a biography. If you are Assaf Friedler and would like to personalize this page please email our Author Liaison for assistance. Publications The Disordered Region of Arabidopsis VIP1 Binds the Agrobacterium VirE2 Protein Outside Its DNA-binding Site Protein Engineering, Design & Selection : PEDS. Nov, 2014 | Pubmed ID: 25212215 A Role of Disordered Domains in Regulating Protein Oligomerization and Stability Chemical Communications (Cambridge, England). Sep, 2014 | Pubmed ID: 25054624 A Tandem in Situ Peptide Cyclization Through Trifluoroacetic Acid Cleavage Angewandte Chemie (International Ed. in English). Sep, 2014 | Pubmed ID: 24827640 Bacterial Magnetosome Biomineralization--a Novel Platform to Study Molecular Mechanisms of Human CDF-related Type-II Diabetes PloS One. 2014 | Pubmed ID: 24819161 Allosteric Modulation of Protein Oligomerization: an Emerging Approach to Drug Design Frontiers in Chemistry. 2014 | Pubmed ID: 24790978 Integrated Strategy Reveals the Protein Interface Between Cancer Targets Bcl-2 and NAF-1 Proceedings of the National Academy of Sciences of the United States of America. Apr, 2014 | Pubmed ID: 24706857 Cation Diffusion Facilitators Transport Initiation and Regulation is Mediated by Cation Induced Conformational Changes of the Cytoplasmic Domain PloS One. 2014 | Pubmed ID: 24658343 A Highly Efficient in Situ N-acetylation Approach for Solid Phase Synthesis Organic & Biomolecular Chemistry. Mar, 2014 | Pubmed ID: 24526269 The STIL Protein Contains Intrinsically Disordered Regions That Mediate Its Protein-protein Interactions Chemical Communications (Cambridge, England). May, 2014 | Pubmed ID: 24022511 Acetylation of Lysine 382 and Phosphorylation of Serine 392 in P53 Modulate the Interaction Between P53 and MDC1 in Vitro PloS One. 2013 | Pubmed ID: 24194938 Characterization of the Translocation-competent Complex Between the Helicobacter Pylori Oncogenic Protein CagA and the Accessory Protein CagF The Journal of Biological Chemistry. Nov, 2013 | Pubmed ID: 24072713 Mapping the Vif-A3G Interaction Using Peptide Arrays: a Basis for Anti-HIV Lead Peptides Bioorganic & Medicinal Chemistry. Jun, 2013 | Pubmed ID: 23545135 Regulation of ASPP2 Interaction with P53 Core Domain by an Intramolecular Autoinhibitory Mechanism PloS One. 2013 | Pubmed ID: 23472201 Monitoring the HIV-1 Integrase Enzymatic Activity Using Atomic Force Microscopy in a 2LTR System Chemical Communications (Cambridge, England). Apr, 2013 | Pubmed ID: 23463374 High Resolution Characterization of Myosin IIC Protein Tailpiece and Its Effect on Filament Assembly The Journal of Biological Chemistry. Apr, 2013 | Pubmed ID: 23426373 Revealing the Ligand Binding Site of NhaA Na+/H+ Antiporter and Its PH Dependence The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 22915592 Peptides That Inhibit HIV-1 Integrase by Blocking Its Protein-protein Interactions The FEBS Journal. Aug, 2012 | Pubmed ID: 22742518 Specific Recognition of P53 Tetramers by Peptides Derived from P53 Interacting Proteins PloS One. 2012 | Pubmed ID: 22693587 A Comparative Study of Backbone Versus Side Chain Peptide Cyclization: Application for HIV-1 Integrase Inhibitors Bioorganic & Medicinal Chemistry. May, 2012 | Pubmed ID: 22507205 Molecular Basis of the Interaction Between Proapoptotic Truncated BID (tBID) Protein and Mitochondrial Carrier Homologue 2 (MTCH2) Protein: Key Players in Mitochondrial Death Pathway The Journal of Biological Chemistry. Apr, 2012 | Pubmed ID: 22416135 Peptides Mimicking the Unique ARTS-XIAP Binding Site Promote Apoptotic Cell Death in Cultured Cancer Cells Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2012 | Pubmed ID: 22392914 A Structural Model of the HIV-1 Rev-integrase Complex: the Molecular Basis of Integrase Regulation by Rev Biochemical and Biophysical Research Communications. Dec, 2011 | Pubmed ID: 22093836 Exposure of Bipartite Hydrophobic Signal Triggers Nuclear Quality Control of Ndc10 at the Endoplasmic Reticulum/nuclear Envelope Molecular Biology of the Cell. Dec, 2011 | Pubmed ID: 21998200 Mechanism of the Interaction Between the Intrinsically Disordered C-terminus of the Pro-apoptotic ARTS Protein and the Bir3 Domain of XIAP PloS One. 2011 | Pubmed ID: 21949740 Chemical Synthesis and Expression of the HIV-1 Rev Protein Chembiochem : a European Journal of Chemical Biology. May, 2011 | Pubmed ID: 21488138 The Effect of Tachykinin Neuropeptides on Amyloid β Aggregation Biochemical and Biophysical Research Communications. Apr, 2011 | Pubmed ID: 21352807 Crowding Alone Cannot Account for Cosolute Effect on Amyloid Aggregation PloS One. 2011 | Pubmed ID: 21249221 Studying Protein-protein Interactions Using Peptide Arrays Chemical Society Reviews. May, 2011 | Pubmed ID: 21243154 Peptides That Bind the HIV-1 Integrase and Modulate Its Enzymatic Activity--kinetic Studies and Mode of Action The FEBS Journal. Jan, 2011 | Pubmed ID: 21156026 Critical Scaffolding Regions of the Tumor Suppressor Axin1 Are Natively Unfolded Journal of Molecular Biology. Jan, 2011 | Pubmed ID: 21087614 From Peptides to Proteins: Lessons from My Years at the Centre for Protein Engineering Protein Engineering, Design & Selection : PEDS. Jan, 2011 | Pubmed ID: 21062759 The ASPP Interaction Network: Electrostatic Differentiation Between Pro- and Anti-apoptotic Proteins Journal of Molecular Recognition : JMR. Mar-Apr, 2011 | Pubmed ID: 20623514 Using Peptides to Study Protein-protein Interactions Future Medicinal Chemistry. Jun, 2010 | Pubmed ID: 21426115 Nucleocytoplasmic Shuttling of HIV-1 Integrase is Controlled by the Viral Rev Protein Nucleus (Austin, Tex.). Mar-Apr, 2010 | Pubmed ID: 21326951 Transportin 3 and Importin α Are Required for Effective Nuclear Import of HIV-1 Integrase in Virus-infected Cells Nucleus (Austin, Tex.). Sep-Oct, 2010 | Pubmed ID: 21326825 Cyclic Peptide Inhibitors of HIV-1 Integrase Derived from the LEDGF/p75 Protein Bioorganic & Medicinal Chemistry. Dec, 2010 | Pubmed ID: 20974536 A Family of Cell-adhering Peptides Homologous to Fibrinogen C-termini Biochemical and Biophysical Research Communications. Oct, 2010 | Pubmed ID: 20833137 Specific Eradication of HIV-1 from Infected Cultured Cells AIDS Research and Therapy. 2010 | Pubmed ID: 20723214 Peptides Derived from the HIV-1 Integrase Promote HIV-1 Infection and Multi-integration of Viral CDNA in LEDGF/p75-knockdown Cells Virology Journal. 2010 | Pubmed ID: 20678206 The C Terminus of P53 Binds the N-terminal Domain of MDM2 Nature Structural & Molecular Biology. Aug, 2010 | Pubmed ID: 20639885 Oxidation of Helix-3 Methionines Precedes the Formation of PK Resistant PrP PLoS Pathogens. 2010 | Pubmed ID: 20625387 Stimulation of the HIV-1 Integrase Enzymatic Activity and CDNA Integration by a Peptide Derived from the Integrase Protein Biopolymers. Aug, 2010 | Pubmed ID: 20517955 Peptide-modified "smart" Hydrogels and Genetically Engineered Stem Cells for Skeletal Tissue Engineering Biomacromolecules. Jun, 2010 | Pubmed ID: 20462241 Structural Disorder in the HIV-1 Vif Protein and Interaction-dependent Gain of Structure Protein and Peptide Letters. Aug, 2010 | Pubmed ID: 20450485 Mechanism of Action of the HIV-1 Integrase Inhibitory Peptide LEDGF 361-370 Biochemical and Biophysical Research Communications. Apr, 2010 | Pubmed ID: 20171172 Over-expression of the HIV-1 Rev Promotes Death of Nondividing Eukaryotic Cells Virus Genes. Jun, 2010 | Pubmed ID: 20151187 A Novel Role for the Viral Rev Protein in Promoting Resistance to Superinfection by Human Immunodeficiency Virus Type 1 The Journal of General Virology. Jun, 2010 | Pubmed ID: 20147519 The Positively Charged Region of the Myosin IIC Non-helical Tailpiece Promotes Filament Assembly The Journal of Biological Chemistry. Mar, 2010 | Pubmed ID: 19959848 Integration of HIV-1 DNA is Regulated by Interplay Between Viral Rev and Cellular LEDGF/p75 Proteins Molecular Medicine (Cambridge, Mass.). Jan-Feb, 2010 | Pubmed ID: 19855849 Novel Regulation of HIV-1 Replication and Pathogenicity: Rev Inhibition of Integration Protein Engineering, Design & Selection : PEDS. Dec, 2009 | Pubmed ID: 19875511 Peptide Inhibitors of HIV-1 Integrase: from Mechanistic Studies to Improved Lead Compounds Bioorganic & Medicinal Chemistry. Nov, 2009 | Pubmed ID: 19850483 A Model for the Interaction Between NF-kappa-B and ASPP2 Suggests an I-kappa-B-like Binding Mechanism Proteins. Nov, 2009 | Pubmed ID: 19507243 The C-terminal Domain of the HIV-1 Vif Protein is Natively Unfolded in Its Unbound State Protein Engineering, Design & Selection : PEDS. May, 2009 | Pubmed ID: 19218568 Peptides Derived from HIV-1 Integrase That Bind Rev Stimulate Viral Genome Integration PloS One. 2009 | Pubmed ID: 19127291 Design and Synthesis of Backbone Cyclic Phosphorylated Peptides: The IkappaB Model Biopolymers. Feb, 2009 | Pubmed ID: 19025995 Molecular Basis of the Interaction Between the Antiapoptotic Bcl-2 Family Proteins and the Proapoptotic Protein ASPP2 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008 | Pubmed ID: 18719108 The Structure and Interactions of the Proline-rich Domain of ASPP2 The Journal of Biological Chemistry. Jul, 2008 | Pubmed ID: 18448430 Synthesis of a Novel Macrocyclic Library: Discovery of an IGF-1R Inhibitor Journal of Combinatorial Chemistry. Mar-Apr, 2008 | Pubmed ID: 18271560 Peptides Derived from HIV-1 Rev Inhibit HIV-1 Integrase in a Shiftide Mechanism Biopolymers. 2008 | Pubmed ID: 18219678 Correlation Between Shiftide Activity and HIV-1 Integrase Inhibition by a Peptide Selected from a Combinatorial Library Journal of Molecular Biology. Feb, 2008 | Pubmed ID: 18201721 Using Peptides to Study the Interaction Between the P53 Tetramerization Domain and HIV-1 Tat Biopolymers. 2008 | Pubmed ID: 18189286 The DNA Damage Response Mediator MDC1 Directly Interacts with the Anaphase-promoting Complex/cyclosome The Journal of Biological Chemistry. Nov, 2007 | Pubmed ID: 17827148 Expression and Characterization of a Novel Reverse Transcriptase of the LTR Retrotransposon Tf1 Virology. Sep, 2007 | Pubmed ID: 17524442 Inhibiting HIV-1 Integrase by Shifting Its Oligomerization Equilibrium Proceedings of the National Academy of Sciences of the United States of America. May, 2007 | Pubmed ID: 17488811 Interaction Between HIV-1 Rev and Integrase Proteins: a Basis for the Development of Anti-HIV Peptides The Journal of Biological Chemistry. May, 2007 | Pubmed ID: 17403681 Butyrylcholinesterase Attenuates Amyloid Fibril Formation in Vitro Proceedings of the National Academy of Sciences of the United States of America. Jun, 2006 | Pubmed ID: 16731619 Modulation of Binding of DNA to the C-terminal Domain of P53 by Acetylation Structure (London, England : 1993). Apr, 2005 | Pubmed ID: 15837201 Binding of Rad51 and Other Peptide Sequences to a Promiscuous, Highly Electrostatic Binding Site in P53 The Journal of Biological Chemistry. Mar, 2005 | Pubmed ID: 15611070 Comparison of BRCT Domains of BRCA1 and 53BP1: a Biophysical Analysis Protein Science : a Publication of the Protein Society. Mar, 2004 | Pubmed ID: 14978302 Binding of P53-derived Ligands to MDM2 Induces a Variety of Long Range Conformational Changes Journal of Molecular Biology. Feb, 2004 | Pubmed ID: 14741215 Structural Distortion of P53 by the Mutation R249S and Its Rescue by a Designed Peptide: Implications for "mutant Conformation" Journal of Molecular Biology. Feb, 2004 | Pubmed ID: 14741214 Rescue of Mutants of the Tumor Suppressor P53 in Cancer Cells by a Designed Peptide Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003 | Pubmed ID: 14595027 Cooperative Organization in a Macromolecular Complex Nature Structural Biology. Sep, 2003 | Pubmed ID: 12897769 Kinetic Instability of P53 Core Domain Mutants: Implications for Rescue by Small Molecules The Journal of Biological Chemistry. Jun, 2003 | Pubmed ID: 12700230 Molecular Mechanism of the Interaction Between MDM2 and P53 Journal of Molecular Biology. Oct, 2002 | Pubmed ID: 12381304 The Structure of an FF Domain from Human HYPA/FBP11 Journal of Molecular Biology. Oct, 2002 | Pubmed ID: 12381297 Human Immunodeficiency Virus Type 1 Vif Binds the Viral Protease by Interaction with Its N-terminal Region The Journal of General Virology. Sep, 2002 | Pubmed ID: 12185277 Two Sequence Motifs from HIF-1alpha Bind to the DNA-binding Site of P53 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2002 | Pubmed ID: 12124396 HIV-1 Vif-derived Peptide Inhibits Drug-resistant HIV Proteases Biochemical and Biophysical Research Communications. Apr, 2002 | Pubmed ID: 11944889 Inhibition of Nuclear Import by Backbone Cyclic Peptidomimetics Derived from the HIV-1 MA NLS Sequence Biochimica Et Biophysica Acta. Feb, 2002 | Pubmed ID: 11904219 A Peptide That Binds and Stabilizes P53 Core Domain: Chaperone Strategy for Rescue of Oncogenic Mutants Proceedings of the National Academy of Sciences of the United States of America. Jan, 2002 | Pubmed ID: 11782540 Identifying Protein-protein Interaction Sites Using Peptide Arrays Hadar Amartely1, Anat Iosub-Amir1, Assaf Friedler1 1Institute of Chemistry, The Hebrew University of Jerusalem JoVE 52097 생물학
Identifying Protein-protein Interaction Sites Using Peptide Arrays Hadar Amartely1, Anat Iosub-Amir1, Assaf Friedler1 1Institute of Chemistry, The Hebrew University of Jerusalem JoVE 52097 생물학